Hs.848 gnl|UG|Hs#S1182 Human immunophilin (FKBP52) mRNA, complete cds 38729_at 23 P

Aliases EC 5.2.1.8 ^3 FKBP52 ^1, 2 FKBP59 ^1, 2, 3 HBI ^2, 3 Hsp56 ^2 PPIase ^2, 3 Rotamase ^3 p52 ^2 rotamase ^2

Descriptions 52 kD FK506 binding protein ^2 52 kDa FK506-binding protein ^3 FK506 binding protein 4 (59kD) ^2 FK506 binding protein 4, 59kDa ^2 FK506 binding protein 52 ^2 FK506-binding protein 4 (59kD) ^1, 2 FKBP52 protein ^3 HSP binding immunophilin ^2 HSP-binding immunophilin ^3 Peptidyl-prolyl cis-trans isomerase ^3 T-cell FK506-binding protein, 59kD ^2 p59 protein ^2, 3 peptidylprolyl cis-trans isomerase ^2

External Ids HGNC: 3720^1 Entrez Gene: 2288^2 UniProtKB: Q02790^3 Ensembl: ENSG00000004478^7

Search outside databases for aliases for FKBP4 gene

Previous GC identifers: GC12P002776 GC12P002797

Summaries
for FKBP4

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EntrezGene summary for FKBP4:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role

in immunoregulation and basic cellular processes involving protein folding and trafficking. This

encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and

rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A),

but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with

FK506. It interacts with interferon regulatory factor-4 and plays an important role in

immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to

associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins

(hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric

forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated

virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene

expression in human cell lines. Thus this encoded protein is thought to have important

implications for the optimal use of AAV vectors in human gene therapy. The human genome contains

several non-transcribed pseudogenes similar to this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790

Function: Component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S.

May have a rotamase activity. May play a role in the intracellular trafficking of heterooligomeric

forms of steroid hormone receptors

Gene Wiki entry for FKBP4 (FKBP52)

Hs.234742 gnl|UG|Hs#S342617 Human salivary peroxidase mRNA, complete cds 34161_at 23 P

Aliases G1 ^2 MGC116862 ^2 MGC116863 ^2 MGC116864 ^2 PRG ^1, 2

Descriptions BstNI type basic salivary proline-rich protein 3 ^2 G1 parotid salivary glycoprotein ^2 Parotid salivary glycoprotein G1 ^3 Proline-rich protein G1 ^3 proline-rich protein BstNI subfamily 3 ^2 proline-rich protein BstNI, subfamily-3 ^2

External Ids HGNC: 9339^1 Entrez Gene: 5544^2 UniProtKB: Q04118^3 Ensembl: ENSG00000197870^7

Search outside databases for aliases for PRB3 gene

Previous GC identifers: GC12U990078 GC12M011564 GC12M011320 GC12M011311 GC12M011312 GC12M011315

Summaries
for PRB3

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EntrezGene summary for PRB3:

The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of

parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other

genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a

lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. [provided by RefSeq]

UniProtKB/Swiss-Prot: PRB3_HUMAN, Q04118

Function: Acts as a receptor for the Gram-negative bacterium F.nucleatum

Gene Wiki entry for PRB3

Hs.90765 gnl|UG|Hs#S551406 Human fibrinogen alpha chain gene, complete mRNAs 38825_at 23 M

Aliases Fib2 ^2 MGC119422 ^2 MGC119423 ^2 MGC119425 ^2

Descriptions fibrinogen alpha chain ^2 fibrinogen, A alpha polypeptide ^1, 2 fibrinogen, alpha chain, isoform alpha preproprotein ^2 fibrinogen, alpha polypeptide ^2

External Ids HGNC: 3661^1 Entrez Gene: 2243^2 UniProtKB: P02671^3 Ensembl: ENSG00000171560^7

Search outside databases for aliases for FGA gene

Previous GC identifers: GC04M156353 GC04M155892 GC04M155970 GC04M156081 GC04M155826

Summaries
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EntrezGene summary for FGA:

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein

comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen

is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In

addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading,

display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia,

afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in

the carboxy-terminus. [provided by RefSeq]

UniProtKB/Swiss-Prot: FIBA_HUMAN, P02671

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and

acting as a cofactor in platelet aggregation

Gene Wiki entry for FGA (Fibrinogen_alpha_chain)

Hs.109052 gnl|UG|Hs#S1090954 Homo sapiens mitochondrial proteolipid 68MP homolog mRNA, nuclear gene encoding mitochondrial protein, complete cds 38967_at 23 P

Aliases ATP5A ^2 ATP5G ^2

Descriptions ATP synthase lipid-binding protein, mitochondrial ^2 ATP synthase proteolipid P1 ^2, 3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 ^2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) ^2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 ^1, 2 ATPase protein 9 ^2, 3 ATPase subunit 9 ^2 ATPase subunit c ^2, 3 mitochondrial ATP synthase, subunit 9, isoform 1 ^2 mitochondrial ATP synthase, subunit C, isoform 1 ^2

External Ids HGNC: 841^1 Entrez Gene: 516^2 UniProtKB: P05496^3 Ensembl: ENSG00000159199^7

Search outside databases for aliases for ATP5G1 gene

Previous GC identifers: GC17P046682 GC17P049450 GC17P047312 GC17P047444

Summaries
for ATP5G1

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EntrezGene summary for ATP5G1:

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP

synthesis, utilizing an electrochemical gradient of protons across the inner membrane during

oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the

soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton

channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits

(alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a

single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d,

e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel.

Each of the three genes have distinct mitochondrial import sequences but encode the identical

mature protein. Alternatively spliced transcript variants encoding the same protein have been

identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: AT5G1_HUMAN, P05496

Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP

from ADP in the presence of a proton gradient across the membrane which is generated by electron

transport complexes of the respiratory chain. F-type ATPases consist of two structural domains,

F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton

channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP

synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk

subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably

10 subunits is part of the complex rotary element

Gene Wiki entry for ATP5G1

Hs.22599 gnl|UG|Hs#S1090825 Homo sapiens mRNA for KIAA0705 protein, complete cds 34257_at 23 P

Aliases ACVRINP1 ^3 ACVRIP1 ^1, 2 AIP1 ^1, 2, 3 ARIP1 ^1, 2 KIAA0705 ^1, 3 MAGI-2 ^1, 2, 3 SSCAM ^2

Descriptions Atrophin-1-interacting protein 1 ^3 Atrophin-1-interacting protein A ^3 Membrane-associated guanylate kinase inverted 2 ^3 activin receptor interacting protein 1 ^2 atrophin 1 interacting protein 1 ^2 atrophin-1 interacting protein A ^2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ^2

External Ids HGNC: 18957^1 Entrez Gene: 9863^2 UniProtKB: Q86UL8^3 Ensembl: ENSG00000187391^7

Search outside databases for aliases for MAGI2 gene

Previous GC identifer: GC07M077292

Summaries
for MAGI2

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EntrezGene summary for MAGI2:

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine

repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This

encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple

PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue

(MAGUK) family. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8

Function: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter

receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in

neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation

Gene Wiki entry for MAGI2

Hs.78465 gnl|UG|Hs#S269129 Human c-jun proto oncogene (JUN), complete cds, clone hCJ-1 1895_at 23 P

Aliases AP-1 ^1, 2 AP1 ^2, 3 OTTHUMP00000010036 ^2 c-Jun ^1, 2 p39 ^3

Descriptions Activator protein 1 ^2, 3 Jun activation domain binding protein ^2 Proto-oncogene c-jun ^3 V-jun avian sarcoma virus 17 oncogene homolog ^1, 2, 3 enhancer-binding protein AP1 ^2 jun oncogene ^2 v-jun sarcoma virus 17 oncogene homolog ^2 v-jun sarcoma virus 17 oncogene homolog (avian) ^1

External Ids HGNC: 6204^1 Entrez Gene: 3725^2 UniProtKB: P05412^3 Ensembl: ENSG00000177606^7

Search outside databases for aliases for JUN gene

Previous GC identifers: GC01M059163 GC01M058161 GC01M058604 GC01M058616

Summaries
for JUN

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EntrezGene summary for JUN:

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which

is highly similar to the viral protein, and which interacts directly with specific target DNA

sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a

chromosomal region involved in both translocations and deletions in human malignancies. [provided

by RefSeq]

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif

5'-TGA[CG]TCA-3'

Gene Wiki entry for JUN (C-jun)

Hs.112378 gnl|UG|Hs#S603 Human PINCH protein mRNA, complete cds 39232_at 23 P

Aliases OTTHUMP00000161608 ^2 PINCH ^1, 2, 3 PINCH-1 ^3 PINCH1 ^1, 2, 3

Descriptions LIM and senescent cell antigen-like domains 1 ^2 Particularly interesting new Cys-His protein 1 ^3 Renal carcinoma antigen NY-REN-48 ^3

External Ids HGNC: 6616^1 Entrez Gene: 3987^2 UniProtKB: P48059^3 Ensembl: ENSG00000169756^7

Search outside databases for aliases for LIMS1 gene

Previous GC identifers: GC02P107110 GC02P107684 GC02P108755 GC02P108772 GC02P108826

Summaries
for LIMS1

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EntrezGene summary for LIMS1:

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double

zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated

interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to

act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in

growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading

cells also suggests that this protein may play a role in integrin-mediated cell adhesion or

spreading. [provided by RefSeq]

UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059

Function: Effector of integrin and growth factor signaling, coupling surface receptors to

downstream signaling molecules involved in the regulation of cell survival, cell proliferation and

cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is

considered to be one of the convergence points of integrin- and growth factor-signaling pathway

Gene Wiki entry for LIMS1

Hs.211569 gnl|UG|Hs#S2628 Human G protein-coupled receptor kinase (GRK5) mRNA, complete cds 40994_at 23 P

ses EC 2.7.11.16 ^3 GPRK5 ^2, 3, 5

Descriptions G protein-coupled receptor kinase 5 ^2 G protein-coupled receptor kinase GRK5 ^3

External Ids HGNC: 4544^1 Entrez Gene: 2869^2 UniProtKB: P34947^3 Ensembl: ENSG00000198873^7

Search outside databases for aliases for GRK5 gene

Previous GC identifer: GC10P120631

Summaries
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EntrezGene summary for GRK5:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor

kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated

forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to

play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by

RefSeq]

UniProtKB/Swiss-Prot: GRK5_HUMAN, P34947

Function: Specifically phosphorylates the activated forms of G protein-coupled receptors

Gene Wiki entry for GRK5

Hs.3830 gnl|UG|Hs#S1367653 Homo sapiens mRNA for KIAA0893 protein, complete cds 35720_at 23 P

Aliases FLJ90135 ^2 KIAA0893 ^1, 2, 3 OTTHUMP00000013443 ^2

Descriptions WD repeat domain 47 ^2

External Ids HGNC: 29141^1 Entrez Gene: 22911^2 UniProtKB: O94967^3 Ensembl: ENSG00000085433^7

Search outside databases for aliases for WDR47 gene

Summaries
for WDR47

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  --

Hs.77239 gnl|UG|Hs#S891922 Homo sapiens mRNA for OCTN1, complete cds 40391_at 23 P

Aliases ETT ^3 MGC34546 ^1, 2 MGC40524 ^2 OCTN1 ^1, 2, 3, 5 UT2H ^3

Descriptions ET transporter ^3 Ergothioneine transporter ^3 Organic cation/carnitine transporter 1 ^3 integral membrane transport protein ^2 solute carrier family 22 (organic cation/ergothioneine transporter), member 4 ^2 solute carrier family 22 member 4 ^2

External Ids HGNC: 10968^1 Entrez Gene: 6583^2 UniProtKB: Q9H015^3 Ensembl: ENSG00000197208^7

Search outside databases for aliases for SLC22A4 gene

Previous GC identifers: GC05P131152 GC05P132077 GC05P131660 GC05P131706

Summaries
for SLC22A4

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EntrezGene summary for SLC22A4:

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are

critical for elimination of many endogenous small organic cations as well as a wide array of drugs

and environmental toxins. The encoded protein is an organic cation transporter and plasma integral

membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding

site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq]

UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015

Function: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium

ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium

(TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is

1.78. A key substrate of this transporter seems to be ergothioneine (ET)

Gene Wiki entry for SLC22A4

Hs.262476 gnl|UG|Hs#S1827 Human S-adenosylmethionine decarboxylase mRNA, complete cds 36684_at 23 P

Aliases ADOMETDC ^2 AMD ^2, 3 AdoMetDC ^3 DKFZp313L1234 ^2 EC 4.1.1.50 ^3 FLJ26964 ^2 OTTHUMP00000017012 ^2 OTTHUMP00000017013 ^2 SAMDC ^1, 2, 3

Descriptions S-adenosylmethionine decarboxylase 1 ^1, 2 adenosylmethionine decarboxylase 1 ^2

External Ids HGNC: 457^1 Entrez Gene: 262^2 UniProtKB: P17707^3 Ensembl: ENSG00000123505^7

Search outside databases for aliases for AMD1 gene

Previous GC identifers: GC06P111031 GC06P111218 GC06P111241

Summaries
for AMD1

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EntrezGene summary for AMD1:

This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines

spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for

cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that

encode different proteins have been identified. [provided by RefSeq]